Details

Autor(en) / Beteiligte

• Garbers, Christoph
• Hermanns, Heike M
• Schaper, Fred
• Müller-Newen, Gerhard
• Grötzinger, Joachim
• Rose-John, Stefan
• Scheller, Jürgen

Titel

Plasticity and cross-talk of Interleukin 6-type cytokines

Ist Teil von

• Cytokine & growth factor reviews, 2012-06, Vol.23 (3), p.85-97

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration and strength of IL-6-type cytokine-mediated signaling is tightly regulated to avoid overshooting activities. Here, molecular mechanisms of inter-familiar cytokine cross-talk are reviewed which regulate dynamics and strength of IL-6 signal transduction. Both plasticity and cytokine cross-talk are significantly involved in pro- and anti-inflammatory/regenerative properties of IL-6-type cytokines. Furthermore, we focus on IL-6-type cytokine/cytokine receptor plasticity and cross-talk exemplified by the recently identified composite cytokines IL-30/IL-6R and IL-35, the first inter-familiar IL-6/IL-12 family member. The complete understanding of the intra- and extracellular cytokine networks will aid to develop novel tailor-made therapeutic strategies with reduced side effects.