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Veterinary immunology and immunopathology, 2012-09, Vol.149 (1-2), p.92-96
2012
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Details

Autor(en) / Beteiligte
Titel
Effects of fructooligosaccharide-inulin on Salmonella-killing and inflammatory gene expression in chicken macrophages
Ist Teil von
  • Veterinary immunology and immunopathology, 2012-09, Vol.149 (1-2), p.92-96
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2012
Quelle
MEDLINE
Beschreibungen/Notizen
  • Salmonella Enteritidis (SE) is one of the leading causes of food-borne salmonellosis, and macrophages play an essential role in eliminating this pathogen. Among the interventions to improve Salmonella clearance in chickens are the use of prebiotics and direct fed microbials (DFM) in animal feed as they have immunomodulatory effects. Therefore, we tested the influence of a prebiotic fructooligosaccharide (FOS)-inulin on the ability of the chicken macrophage HD11 cell line to phagocytose and kill SE, and express selected inflammatory cytokines and chemokines in an in vitro model. There were significantly fewer viable intracellular SE in HD11 cells treated with FOS-inulin than the untreated cells. However, SE phagocytosis, nitric oxide expression or production were not influenced by the prebiotic treatment. Among the inflammatory markers tested, IL-1β expression was significantly lower in HD11 cells treated with FOS-inulin. These results suggest that FOS-inulin has the ability to modulate the innate immune system as shown by the enhanced killing of SE and decreased inflammasome activation.

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