Biomarkers in medicine, 2012-08, Vol.6 (4), p.441-454
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Plasma biomarkers for Alzheimer's disease: much needed but tough to find
- Ist Teil von
- Biomarkers in medicine, 2012-08, Vol.6 (4), p.441-454
- Ort / Verlag
- England: Future Medicine Ltd
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Alzheimer's disease is a complex age-dependent neurodegenerative disease where definitive diagnosis is only possible after autopsy and where there is a long prodromal or preclinical phase. Biomarkers for both early diagnosis and prediction of disease progression are needed and extensive efforts to discover them have been undertaken. In this article, we have attempted to summarize the findings of current studies using proteomics and metabolomics approaches. We are also discussing how the use of emerging technologies and better study designs can support the identification of the much-needed Alzheimer's disease plasma biomarkers.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1752-0363eISSN: 1752-0371DOI: 10.2217/bmm.12.48Titel-ID: cdi_proquest_miscellaneous_1035104817
- Format
- –
- Schlagworte
- Alzheimer Disease - diagnosis, Alzheimer Disease - metabolism, Alzheimer Disease - pathology, Alzheimer's disease, Amyloid beta-Peptides - blood, Analysis, Biological markers, Biomarkers, Biomarkers - blood, Blood plasma, Cerebrospinal fluid, Clinical trials, Cognitive ability, Development and progression, Diagnosis, Health aspects, Humans, Intellectual property, Metabolomics, Pathology, Peptide Fragments - blood, Pharmaceutical industry, Physiological aspects, Plasma, Proteomics, Regulatory approval, Research Design, Small & medium sized enterprises-SME, Technological change