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  • BibTeX
The ERalpha/ERbeta ratio determines oxidative stress in breast cancer cell lines in response to 17Beta-estradiol
Journal of cellular biochemistry, 2012-10, Vol.113 (10), p.3178-3185
2012

Details

Autor(en) / Beteiligte
Titel
The ERalpha/ERbeta ratio determines oxidative stress in breast cancer cell lines in response to 17Beta-estradiol
Ist Teil von
  • Journal of cellular biochemistry, 2012-10, Vol.113 (10), p.3178-3185
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
  • The effects of 17beta‐estradiol (E2) are mediated through activation of estrogen receptors (ER): ERalpha and ERbeta. It is known that ERalpha/ERbeta ratio is higher in breast tumors than in normal tissue. Since antioxidant enzymes and uncoupling proteins (UCPs) are reactive oxygen species (ROS) production and mitochondrial biogenesis regulators, our aim was to study the E2‐effect on oxidative stress, antioxidant enzyme expression, and UCPs in breast cancer cell lines with different ERalpha/ERbeta ratios. The lower ERalpha/ERbeta ratio T47D cell line showed low ROS production and high UCP5 levels. However, the higher ERalpha/ERbeta ratio MCF‐7 cell line showed an up‐regulation of antioxidant enzymes and UCPs, yet exhibited high oxidative stress. As a result, a decrease in antioxidant enzyme activities and UCP2 protein levels, coupled with an increase in oxidative damage was found. On the whole, these results show different E2‐effects on oxidative stress regulation, modulating UCPs, and antioxidant enzymes, which were ERalpha/ERbeta ratio dependent in breast cancer cell lines. J. Cell. Biochem. 113: 3178–3185, 2012. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0730-2312
eISSN: 1097-4644
DOI: 10.1002/jcb.24192
Titel-ID: cdi_proquest_miscellaneous_1033457628
Format
–
Schlagworte
ANTIOXIDANT ENZYMES, Antioxidants - metabolism, BREAST CANCER, Catalase - analysis, Catalase - metabolism, Cell Proliferation - drug effects, Enzyme Activation, ERalpha/ERbeta RATIO, Estradiol - pharmacology, Estrogen Receptor alpha - genetics, Estrogen Receptor alpha - metabolism, Estrogen Receptor beta - genetics, Estrogen Receptor beta - metabolism, ESTROGEN RECEPTORS, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Ion Channels - genetics, Ion Channels - metabolism, MCF-7 Cells, Membrane Potential, Mitochondrial, Membrane Transport Proteins - genetics, Membrane Transport Proteins - metabolism, Mitochondrial Proteins - genetics, Mitochondrial Proteins - metabolism, Mitochondrial Turnover, Mitochondrial Uncoupling Proteins, Nerve Tissue Proteins - genetics, Nerve Tissue Proteins - metabolism, OXIDATIVE STRESS, REACTIVE OXYGEN SPECIES, Reactive Oxygen Species - metabolism, Superoxide Dismutase - genetics, Superoxide Dismutase - metabolism, Uncoupling Protein 2

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