Details

Autor(en) / Beteiligte

• Zhou, Feng
• Liu, Yun-Lin
• Zhou, Jian

Titel

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

Ist Teil von

• Advanced synthesis & catalysis, 2010-06, Vol.352 (9), p.1381-1407

Ort / Verlag

Weinheim: WILEY-VCH Verlag

Erscheinungsjahr

2010

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• The 3,3′‐disubstituted oxindole structural motif is a prominent feature in many alkaloid natural products, which include all kinds of tetrasubstituted carbon stereocenters, spirocyclic or not, all‐carbon or heteroatom‐containing. The catalytic asymmetric synthesis of the tetrasubstituted carbon stereocenter at the C‐3 position of the oxindole framework integrates new synthetic methods and chiral catalysts, reflects the latest achievements in asymmetric catalysis, and facilitates the synthesis of sufficient quantities of related compounds as potential medicinal agents and biological probes. This review summarizes the recent progress in this area, and applications in the total synthesis of related bioactive compounds.