Journal of neurochemistry, 2012-08, Vol.122 (3), p.545-556
2012
Details
- Autor(en) / Beteiligte
- Titel
- Ammonia-induced deficit in corticostriatal long-term depression and its amelioration by zaprinast
- Ist Teil von
- Journal of neurochemistry, 2012-08, Vol.122 (3), p.545-556
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- J. Neurochem. (2012) 122, 545–556. Hyperammonemia is a major pathophysiological factor in encephalopathies associated with acute and chronic liver failure. On mouse brain slice preparations, we analyzed the effects of ammonia on the characteristics of corticostriatal long‐term depression (LTD) induced by electrical stimulation of cortical input or pharmacological activation of metabotropic glutamate receptors. Long exposure of neostriatal slices to ammonium chloride impaired the induction and/or expression of all studied forms of LTD. This impairment was reversed by the phosphodiesterase inhibitor zaprinast implying lowered cGMP signaling in LTD suppression. Polyphenols from green tea rescued short‐term corticostriatal plasticity, but failed to prevent the ammonia‐induced deficit of LTD. Zaprinast counteracts the ammonia‐induced impairment of long‐term corticostriatal plasticity and may thus improve fine motor skills and procedural learning in hepatic encephalopathy. Inhibition of cGMP hydrolysis by zaprinast rescues generation of corticostriatal long‐term depression (LTD) impaired by ammonia. LTD evoked by electrical (Tetanus, 10 Hz, 100 Hz on cortical axons) and chemical stimulation (DHPG, mGluRI agonist bath applied to medium spiny neuron in a slice preparation) is mediated by mGluR1/5, endocannabinoids, and NO. Superimposed field potentials show from left to right: stimulus artifact, sa, cortical fiber volley, fv, synaptically evoked response, syn (of striatal medium spiny neurons).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3042eISSN: 1471-4159DOI: 10.1111/j.1471-4159.2012.07806.xTitel-ID: cdi_proquest_miscellaneous_1028033011
- Format
- –
- Schlagworte
- Aminoacid disorders, Ammonia, Ammonia - pharmacology, Ammonium chloride, Animals, Antioxidants - pharmacology, Axons, Biological and medical sciences, Biophysics, Brain slice preparation, Cannabinoids, Cerebral Cortex - cytology, Cerebral Cortex - drug effects, Cerebral Cortex - physiology, Corpus Striatum - cytology, Corpus Striatum - drug effects, Corpus Striatum - physiology, Cortex, Cyclic GMP, Cycloheximide - pharmacology, DHPG, Drug Interactions, Electric Stimulation, Errors of metabolism, Fibers, Gastroenterology. Liver. Pancreas. Abdomen, Glutamic acid receptors (metabotropic), green tea, green tea polyphenols, hyperammonemia, In Vitro Techniques, Liver diseases, Liver. Biliary tract. Portal circulation. Exocrine pancreas, Long-term depression, Long-Term Synaptic Depression - drug effects, Male, Medical sciences, Metabolic diseases, Methoxyhydroxyphenylglycol - analogs & derivatives, Methoxyhydroxyphenylglycol - pharmacology, Mice, Mice, Inbred C57BL, Motor ability, Motor skill learning, Neostriatum, Neurochemistry, Neurological disorders, Other diseases. Semiology, Phosphodiesterase Inhibitors - pharmacology, Plasticity, Polyphenols - pharmacology, Protein Synthesis Inhibitors - pharmacology, Purinones - pharmacology, spiny neurons, striatum, Synapses - drug effects, zaprinast