Details

Autor(en) / Beteiligte

• Cardoso, Enedina Jiménez
• Valdéz, Guillermina Campos
• Campos, Adrián Cortes
• Sanchez, Rene de la Luz
• Mendoza, Carlos Rivera
• Hernández, Arturo Plascencia
• Ramírez, María Hernández
• Habana, Joel Ruiz
• González, Edmundo Bonilla
• Matzumura, Pablo Damian
• Carlier, Yves

Titel

Maternal fetal transmission of Trypanosoma cruzi: A problem of public health little studied in Mexico

Ist Teil von

• Experimental parasitology, 2012-08, Vol.131 (4), p.425-432

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2012

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• [Display omitted] ► The seroprevalence of Trypanosoma cruzi in pregnant women was analyzed in two states of Mexico. ► The rates and consequences of maternal–fetal transmission were determined by serology. ► Is necessary to determine the risk factors associated with vertical transmission of T. cruzi. ► The treatment should be administrated immediately after the diagnostic. The first case of neonatal Chagas was reported in Mexico in 1998, but there have been no studies since then. Therefore, we investigated the rates of congenital infection of Trypanosoma cruzi by examining the seroprevalence among 1448 pregnant women in Oaxaca, Jalisco and Mexico City. We performed ELISAs to screen for recombinant and total antigens in mothers, and examined the frequency of congenital T. cruzi transmission by PCR with cord blood and antibody testing in children when they reached two years old. Our results showed that the prevalence of infection in pregnant women was 7.32% (106/1448) overall, and 4.4% (35/794) in Oaxaca, 12.02% (67/557) in Jalisco and 4.12% (4/97) in the Mexico City. In Oaxaca, T. cruzi infection was detected by PCR in 20% (7/35) of infants born to seroreactive mothers and 11.9% (8/67) in Jalisco. No infections were identified in infants from the Mexico City. From these only eleven serological follow up their children are agree to take blood. Therefore, the maternal–fetal overall transmission rate was 4.08% (4/98) in Oaxaca and 9.1% (3/33) in Jalisco 1.5% (1/65) children with positive serology were given specific treatment Chagas. In conclusion, these are the first reports of the rates of congenital Chagas disease in Mexico. The seroprevalence was higher in mothers from Jalisco, and could be related to that there is not the periodic fumigation of the transmitting vector performed in that state. The high rates of maternal–fetal transmission found in Oaxaca could be related to the differences of pathogenicity of trypanosome. No association between both the rate of congenital transmission and the gynecologic anthropometric data was observed.