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Differential Effects of Chlorogenic Acid on Various Immunological Parameters Relevant to Rheumatoid Arthritis
Phytotherapy research, 2012-08, Vol.26 (8), p.1156-1165
Chauhan, Prashant Singh
Satti, Naresh Kumar
Sharma, Punita
Sharma, Vijay Kumar
Suri, Krishan Avtar
Bani, Sarang
2012
Details
Autor(en) / Beteiligte
Chauhan, Prashant Singh
Satti, Naresh Kumar
Sharma, Punita
Sharma, Vijay Kumar
Suri, Krishan Avtar
Bani, Sarang
Titel
Differential Effects of Chlorogenic Acid on Various Immunological Parameters Relevant to Rheumatoid Arthritis
Ist Teil von
Phytotherapy research, 2012-08, Vol.26 (8), p.1156-1165
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Despite chlorogenic acid (CGA) being widely present in nature, particularly in the human diet, there is very little information regarding its pharmacological activities. The present investigation was carried out to investigate the antiarthritic activities of this compound in adjuvant induced‐arthritis in male Wistar rats, and to explore the underlying mechanisms of actions in view of immunological responses. We observed that CGA effectively controlled the total (CD3) and differentiated (CD4 and CD8) T cells count at the dose of 40 mg/kg. We also assessed the effect on co‐stimulatory molecules (CD28, CD80/86) and found that CGA efficiently suppressed CD80/86 but failed to bring any changes in the CD28 count, whereas ibuprofen (standard drug) resulted in highly significant inhibition of both. We next examined the effect on CD4+ T cells specific Th1/Th2 cytokines by flow cytometry and observed that CGA suppressed the Th1 cytokines in a highly significant manner but elevated Th2 cytokines with dose dependence. Results of the present investigation suggest that CGA is a potent antiarthritic agent. Copyright © 2011 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.3684
Titel-ID: cdi_proquest_miscellaneous_1027682052
Format
–
Schlagworte
Animals
,
Antirheumatic Agents - administration & dosage
,
Antirheumatic Agents - therapeutic use
,
Arthritis, Experimental - chemically induced
,
Arthritis, Experimental - drug therapy
,
Arthritis, Experimental - immunology
,
Arthritis, Experimental - pathology
,
B7-1 Antigen - immunology
,
B7-2 Antigen - immunology
,
Biological and medical sciences
,
CD28 Antigens - immunology
,
CD3 Complex - immunology
,
CD4-Positive T-Lymphocytes - drug effects
,
CD4-Positive T-Lymphocytes - immunology
,
CD8-Positive T-Lymphocytes - drug effects
,
CD8-Positive T-Lymphocytes - immunology
,
Chlorogenic acid
,
Chlorogenic Acid - administration & dosage
,
Chlorogenic Acid - therapeutic use
,
co-stimulatory molecules
,
cytokines
,
Dose-Response Relationship, Immunologic
,
Drug Evaluation, Preclinical
,
Female
,
Flow Cytometry
,
General pharmacology
,
Hypersensitivity, Delayed - immunology
,
Ibuprofen - immunology
,
Lymphocyte Count
,
Male
,
Medical sciences
,
Mice
,
Mycobacterium tuberculosis - immunology
,
Pharmacognosy. Homeopathy. Health food
,
Pharmacology. Drug treatments
,
Phytotherapy
,
Rats
,
Rats, Wistar
,
T cells
,
Th1-Th2 Balance
,
Toxicity Tests, Acute
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