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Expression of cancer-testis antigens MAGE-A4 and MAGE-C1 in oral squamous cell carcinoma
Head & neck, 2012-08, Vol.34 (8), p.1123-1128
Montoro, José Raphael de Moura Campos
Mamede, Rui Celso Martins
Neder Serafini, Luciano
Saggioro, Fabiano Pinto
Figueiredo, David Livingstone Alves
Silva Jr, Wilson Araújo da
Jungbluth, Achim A.
Spagnoli, Giulio Cesare
Zago, Marco Antônio
2012
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Montoro, José Raphael de Moura Campos
Mamede, Rui Celso Martins
Neder Serafini, Luciano
Saggioro, Fabiano Pinto
Figueiredo, David Livingstone Alves
Silva Jr, Wilson Araújo da
Jungbluth, Achim A.
Spagnoli, Giulio Cesare
Zago, Marco Antônio
Titel
Expression of cancer-testis antigens MAGE-A4 and MAGE-C1 in oral squamous cell carcinoma
Ist Teil von
Head & neck, 2012-08, Vol.34 (8), p.1123-1128
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background Tumor markers are genes or their products expressed exclusively or preferentially in tumor cells and cancer‐testis antigens (CTAs) form a group of genes with a typical expression pattern expressed in a variety of malignant neoplasms. CTAs are considered potential targets for cancer vaccines. It is possible that the CTA MAGE‐A4 (melanoma antigen) and MAGE‐C1 are expressed in carcinoma of the oral cavity and are related with survival. Methods This study involved immunohistochemical analysis of 23 patients with oral squamous cell carcinoma (SCC) and was carried out using antibodies for MAGE‐A4 and MAGE‐C1. Fisher's exact test and log‐rank test were used to evaluate the results. Results The expression of the MAGE‐A4 and MAGE‐C1 were 56.5% and 47.8% without statistical difference in studied variables and survival. Conclusion The expression of at least 1 CTA was present in 78.3% of the patients, however, without correlation with clinicopathologic variables and survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Sprache
Englisch
Identifikatoren
ISSN: 1043-3074
eISSN: 1097-0347
DOI: 10.1002/hed.21880
Titel-ID: cdi_proquest_miscellaneous_1027370412
Format
–
Schlagworte
Adult
,
Aged
,
Alcohol Drinking - epidemiology
,
Antigens, Neoplasm - genetics
,
Biological and medical sciences
,
biological tumor markers
,
Biomarkers, Tumor - genetics
,
Carcinoma, Squamous Cell - genetics
,
Carcinoma, Squamous Cell - immunology
,
Carcinoma, Squamous Cell - mortality
,
Female
,
Humans
,
Immunohistochemistry
,
MAGE-A4
,
MAGE-C1
,
Male
,
Medical sciences
,
Middle Aged
,
mouth neoplasms
,
Mouth Neoplasms - genetics
,
Mouth Neoplasms - immunology
,
Mouth Neoplasms - mortality
,
Neoplasm Proteins - genetics
,
Otorhinolaryngology. Stomatology
,
Smoking - epidemiology
,
Tumors
,
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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