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Medullary thyroid carcinoma with nodular goiter carries an excellent prognosis
Journal of surgical oncology, 2012-08, Vol.106 (2), p.169-173
Xu, Lai
Wang, Wei-Bin
Zhao, Yu-Pei
Zhang, Tai-Ping
Liao, Quan
Chen, Ge
Zhou, Li
Shu, Hong
2012
Details
Autor(en) / Beteiligte
Xu, Lai
Wang, Wei-Bin
Zhao, Yu-Pei
Zhang, Tai-Ping
Liao, Quan
Chen, Ge
Zhou, Li
Shu, Hong
Titel
Medullary thyroid carcinoma with nodular goiter carries an excellent prognosis
Ist Teil von
Journal of surgical oncology, 2012-08, Vol.106 (2), p.169-173
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Background In our institution, patients with medullary thyroid carcinoma (MTC) concurrent with nodular goiter (NG) have a nearly 100% survival rate, but the reasons and characteristics are unclear. Methods Eighty patients with MTC who underwent surgery in our center between 1971 and 2011 were reviewed. Results A total of 21 MTC/NG and 59 MTC only patients were identified. The stage of the two groups had no significant difference (P = 0.13). The MTC/NG group had lower preoperative serum calcitonin (CT) levels (914.7 ng/L vs. 1162.6 ng/L, P = 0.003), lower postoperative serum CT levels (371.4 ng/L vs. 582.5 ng/L, P < 0.001), lower carcinoembryonic antigen levels (18.3 ng/ml vs. 130.5 ng/ml, P < 0.001), a lower propensity toward lymph node metastasis (40.0% vs. 66.7%, P = 0.07), and a lower proportion of multifocality (19.1% vs. 42.4%, P = 0.06), capsular invasion (9.5% vs. 25.4%, P = 0.21), and vascular invasion (4.8% vs. 10.1%, P = 0.67). The mean tumor diameter of the two groups was similar (20.3 mm vs. 22.1 mm, P = 0.6). Overall 15‐year survival in MTC/NG versus MTC only groups was 100% versus 57.0% (P = 0.03). Conclusions MTC with NG is an indolent disease and has an excellent prognosis. The only independent predictor of survival was the TNM stage of disease. J. Surg. Oncol. 2012; 106:169–173. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0022-4790
eISSN: 1096-9098
DOI: 10.1002/jso.23070
Titel-ID: cdi_proquest_miscellaneous_1024476983
Format
–
Schlagworte
Adolescent
,
Adult
,
Aged
,
Analysis of Variance
,
Biomarkers, Tumor - blood
,
Calcitonin - blood
,
Carcinoembryonic Antigen - blood
,
Carcinoma, Medullary - mortality
,
Carcinoma, Medullary - pathology
,
Carcinoma, Medullary - surgery
,
China - epidemiology
,
Female
,
Goiter, Nodular - mortality
,
Goiter, Nodular - pathology
,
Goiter, Nodular - surgery
,
Humans
,
Kaplan-Meier Estimate
,
Lymphatic Metastasis
,
Male
,
medullary thyroid carcinoma
,
Middle Aged
,
Neoplasm Invasiveness
,
Neoplasm Staging
,
Nervous System Neoplasms - secondary
,
nodular goiter
,
Prognosis
,
Retrospective Studies
,
Risk Factors
,
Sample Size
,
survival
,
Thyroid Neoplasms - mortality
,
Thyroid Neoplasms - pathology
,
Thyroid Neoplasms - surgery
,
Thyroidectomy
,
Vascular Neoplasms - secondary
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