Details

Autor(en) / Beteiligte

• Sharma, Purva, MD
• Kuperman, Michael, MD
• Racusen, Lorraine, MD
• Geetha, Duvuru, MD

Titel

Fibrillary Glomerulonephritis Presenting as Rapidly Progressive Glomerulonephritis

Ist Teil von

• American journal of kidney diseases, 2012-07, Vol.60 (1), p.157-159

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Fibrillary glomerulonephritis (GN) is an uncommon cause of rapidly progressive kidney failure. We report a case of rapidly progressive kidney failure with kidney biopsy showing crescentic GN on light microscopy and immunofluorescence showing linear/globular glomerular basement membrane (GBM) staining for immunoglobulin G and C3, consistent with anti-GBM disease. However, electron microscopy showed fibrillary deposits in the GBM, suggesting a diagnosis of fibrillary GN. As exemplified by this case, it is important to consider fibrillary GN in the differential diagnosis of crescentic GN with linear immunoglobulin G deposits within the GBM. Electron microscopy is crucial to make this diagnosis.