Details

Autor(en) / Beteiligte

• Salvo, Lígia M
• Bainy, Afonso C. D
• Ventura, Eliana C
• Marques, Maria R. F
• Silva, José Roberto M. C
• Klemz, Cláudio
• Silva de Assis, Helena C

Titel

Assessment of the sublethal toxicity of organochlorine pesticide endosulfan in juvenile common carp (Cyprinus carpio)

Ist Teil von

• Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 2012-09, Vol.47 (11), p.1652-1658

Ort / Verlag

Philadelphia, PA: Taylor & Francis Group

Erscheinungsjahr

2012

Quelle

Taylor & Francis

Beschreibungen/Notizen

• This study is aimed at evaluating the sublethal effects of endosulfan (EDS) in juvenile common carp (Cyprinus carpio). For this purpose, fish were exposed for 15 days to the technical EDS (95% pure) diluted in dimethyl sulfoxide (DMSO) 0.1% of the total volume in water solution in a semi-static system at sublethal concentration (1 μg/L). Subsequently, the liver somatic index (LSI) and factor condition (K) were determined. The total cytocrome P450 (CYP), CYP1A isoform, and the ethoxyresorufin-O-deethylase (EROD) activity were determined from the hepatic microsomal fraction as well as the activity of the oxidative stress enzyme system such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPX), glutathione reductase (GR), and glucose-6-phosphate dehydrogenase (G6PDH). Among the parameters assessed, EDS at the sublethal concentration in subchronic exposure caused significant changes in liver somatic indices as well as induction of the phase I biotransformation system and oxidative stress in juvenile common carp (Cyprinus carpio). Thus, it is seen that the use of biochemical biomarkers of environmental contamination in this study proved to be an extremely important tool for detecting the adverse effects of xenobiotics in the aquatic environment, even at low concentration.