Gene, 2012-06, Vol.501 (2), p.219-221
2012
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- Autor(en) / Beteiligte
- Titel
- Lytic bone disease as the presenting feature of Philadelphia-positive monosomy 7 myelodysplasia progressing to acute myeloid leukaemia
- Ist Teil von
- Gene, 2012-06, Vol.501 (2), p.219-221
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We describe an unusual case of Philadelphia-positive, monosomy 7 myelodysplasia progressing to acute myeloid leukaemia in a 53year old male who presented with bone-pain and B-symptoms and was found to have diffuse osteolytic lesions. Molecular genetic analysis revealed both b3a2 and e1a2 t(9;22) transcripts. Cytogenetic analysis was an additional useful test in determining the course and management of an atypical BCR-ABL positive myelodysplasia.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0378-1119eISSN: 1879-0038DOI: 10.1016/j.gene.2012.04.024Titel-ID: cdi_proquest_miscellaneous_1020858289
- Format
- –
- Schlagworte
- Antineoplastic Agents - therapeutic use, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Benzamides, Bone Diseases - diagnosis, Bone Diseases - diagnostic imaging, Bone Diseases - drug therapy, Bone Diseases - genetics, Chromosome Deletion, Chromosomes, Human, Pair 19 - genetics, Chromosomes, Human, Pair 7 - genetics, Chromosomes, Human, Pair 9 - genetics, Cytarabine - therapeutic use, cytogenetic analysis, Humans, Idarubicin - therapeutic use, Imatinib Mesylate, leukemia, Leukemia, Myeloid, Acute - diagnosis, Leukemia, Myeloid, Acute - diagnostic imaging, Leukemia, Myeloid, Acute - drug therapy, Leukemia, Myeloid, Acute - genetics, Lytic, Male, Middle Aged, monosomics, Monosomy 7, Myelodysplasia, Myelodysplastic Syndromes - diagnosis, Myelodysplastic Syndromes - diagnostic imaging, Myelodysplastic Syndromes - drug therapy, Myelodysplastic Syndromes - genetics, Myeloid, Pain - diagnosis, Pain - genetics, Philadelphia, Philadelphia Chromosome, Piperazines - therapeutic use, Protein Kinase Inhibitors - therapeutic use, Pyrimidines - therapeutic use, Radiography, Vidarabine - analogs & derivatives, Vidarabine - therapeutic use