Details

Autor(en) / Beteiligte

• Bouabe, H.

Titel

Cytokine Reporter Mice: The Special Case of IL-10

Ist Teil von

• Scandinavian journal of immunology, 2012-06, Vol.75 (6), p.553-567

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• IL‐10 is one of the key cytokines preventing inflammation‐mediated tissue damage. In an attempt to identify IL‐10‐producing cells in vivo, several groups have recently developed IL‐10 reporter mouse strains. Up until now, in total, eight IL‐10 reporter strains have been published. This incomparable interest in IL‐10 reporter mice emphasizes the importance and difficulties in tracking and subsequently investigating the role of IL‐10‐producing cells in infectious, inflammatory, autoimmune and cancer diseases. In this review, I summarize and compare the properties of those published IL‐10 reporter mouse models. I also discuss the necessity to develop new strategies to generate ‘multi‐cytokine’ reporter mouse models enabling highly sensitive in/ex vivo detection of many cytokines in the same single cell. Such ‘multi‐cytokine’ reporter mice will enable to reconsider the dichotomy ‘T‐effector versus T‐regulatory’ paradigm and to provide an accurate revised model for cellular sources of cytokines. Finally, I propose to launch cooperative, international initiatives to promote and coordinate the generation of accurate, combinatorial, reporter mice for every individual murine cytokine.