Details

Autor(en) / Beteiligte

• Oliveira-Neto, Helenisa Helena, DDS, MS
• Gleber-Netto, Frederico Omar, DDS
• de Sousa, Sílvia Ferreira, DDS
• França, Cristiane Miranda, DDS, MS, PhD
• Aguiar, Maria Cássia Ferreira, DDS, MS, PhD
• Silva, Tarcília Aparecida, DDS, MS, PhD
• Batista, Aline Carvalho, DDS, MS, PhD

Titel

A comparative study of microvessel density in squamous cell carcinoma of the oral cavity and lip

Ist Teil von

• Oral surgery, oral medicine, oral pathology and oral radiology, 2012-03, Vol.113 (3), p.391-398

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives The objective of this study was to comparatively evaluate the density of lymphatic vessels (LVD) and neoformed microvessels (NMVD) in squamous cell carcinoma of the oral cavity (OCSCC) and lip (LSCC). Association between LVD/NMVD and vascular endothelial growth factor (VEGF)-A/-C was also assessed. Study Design OCSCC and LSCC were compared with regard to immunoexpression of LVD, NMVD, and vascular endothelial growth factor-A (VEGF)-A/-C. Association between VEGF-A/-C with vascularity was also assessed. Statistical analyses were performed using t test, Pearson χ2 , and Mann-Whitney tests. Statistical significance was accepted at P less than .05. Results The NMVD and VEGF-C expressions were significantly higher in OCSCC compared with LSCC. NMVD was associated with VEGF-C in OCSCC, but not in LSCC. Conclusions Differences in NMVD and VEGF-C were found between OCSCC and LSCC. Positive association between VEGF-C and NMVD was observed in OCSCC, but not in LSCC, which may be one of the contributing factors that account for the distinctive clinical-biological behavior of these lesions.