Details

Autor(en) / Beteiligte

• Nasr, Samih H., MD
• Valeri, Anthony M., MD
• Sethi, Sanjeev, MD, PhD
• Fidler, Mary E., MD
• Cornell, Lynn D., MD
• Gertz, Morie A., MD
• Lacy, Martha, MD
• Dispenzieri, Angela, MD
• Rajkumar, S. Vincent, MD
• Kyle, Robert A., MD
• Leung, Nelson, MD

Titel

Clinicopathologic Correlations in Multiple Myeloma: A Case Series of 190 Patients With Kidney Biopsies

Ist Teil von

• American journal of kidney diseases, 2012-06, Vol.59 (6), p.786-794

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

2012

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Renal involvement is common in multiple myeloma. In this study, we examined kidney biopsy findings in patients with multiple myeloma and correlated them with their clinical renal and hematologic characteristics. Study Design Case series. Setting & Participants 190 Mayo Clinic patients with multiple myeloma who underwent kidney biopsy between 1997-2011 were identified from our kidney biopsy database. Patients had an established diagnosis of multiple myeloma or multiple myeloma was diagnosed shortly after the results of kidney biopsy, which prompted bone marrow biopsy. Predictors Myeloma cast nephropathy (MCN), AL amyloidosis, and monoclonal immunoglobulin deposition disease (MIDD). Outcomes & Measurements Renal morphologic changes, clinical renal and hematologic characteristics at kidney biopsy, renal and patient outcomes. Results Paraprotein-associated lesions were seen in 73% of patients; non–paraprotein-associated lesions, in 25%; and no pathology, in 2%. The most common paraprotein-associated lesions were MCN (33%), MIDD (22%), and amyloidosis (21%). The most common non–paraprotein-associated lesions were acute tubular necrosis (9%), hypertensive arteriosclerosis (6%), and diabetic nephropathy (5%). Patients with MIDD were younger than those with MCN or amyloidosis. Urine paraprotein size and bone marrow plasma cell percentage were higher in MCN than amyloidosis or MIDD. Nephrotic syndrome was more common in amyloidosis than MIDD. Percentage of albuminuria was highest in amyloidosis and lowest in MCN. Median kidney survival from kidney biopsy was 20, 30, and 51 months for MCN, amyloidosis, and MIDD, respectively ( P = 0.2). Median patient survival from multiple myeloma diagnosis was 44, 58, and 62 months for MCN, amyloidosis, and MIDD, respectively ( P = 0.4). Limitations Retrospective nature. Conclusions The spectrum of renal lesions in multiple myeloma is more heterogeneous than previously reported. Clinical features favoring amyloidosis over MIDD include older age, absence of kidney failure, presence of nephrotic syndrome, absence of hematuria, and >50% albuminuria.