Vaccine, 2012-05, Vol.30 (22), p.3295-3303
2012
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- Autor(en) / Beteiligte
- Titel
- Safety and immunogenicity of a novel human Enterovirus 71 (EV71) vaccine: A randomized, placebo-controlled, double-blind, Phase I clinical trial
- Ist Teil von
- Vaccine, 2012-05, Vol.30 (22), p.3295-3303
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2012
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Highlights ► HFMD outbreaks cause high mortality in mainland China since 2008. ► Enterovirus 71 (EV71) was associated with high-mortality HFMD outbreaks. ► EV71 vaccine will be the most effective measure to reduce morbidity and mortality. ► The Phase I clinical study evaluated safety and immunogenicity of EV71 vaccine. ► EV71 was well tolerated and highly immunogenic in healthy subjects.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410XeISSN: 1873-2518DOI: 10.1016/j.vaccine.2012.03.010Titel-ID: cdi_proquest_miscellaneous_1014110230
- Format
- –
- Schlagworte
- Adolescent, Adult, adults, Allergy and Immunology, Aluminum, Antibodies, Antibodies, Neutralizing - blood, Antibodies, Viral - blood, Antigens, Child, Child, Preschool, Children, Clinical trials, Confidence intervals, Double-Blind Method, Drug dosages, Drug-Related Side Effects and Adverse Reactions - epidemiology, Enterovirus 71, Enterovirus A, Enterovirus A, Human - immunology, EV71 vaccine, Female, Healthy Volunteers, Human enterovirus 71, Humans, Immune response, Immunization, Immunogenicity, Infant, Infants, Injections, Intramuscular, intramuscular injection, Male, Middle Aged, Mortality, neutralizing antibodies, Placebos - administration & dosage, Safety, seroprevalence, Vaccination, Vaccination - adverse effects, Vaccination - methods, Vaccines, Viral Vaccines - administration & dosage, Viral Vaccines - adverse effects, Viral Vaccines - immunology, volunteers, Young Adult