Details

Autor(en) / Beteiligte

• Nozaki, Hiroshi
• Hayashi, Ken-ichiro
• Kawai, Mikiko
• Mitsui, Taichi
• Kido, Masahiro
• Tani, Hiroyuki
• Takaoka, Daisuke
• Uno, Hidemitsu
• Ohira, Susumu
• Kuboki, Atsuto
• Matsuura, Nobuyasu

Titel

Culcitiolides A-D, Four New Eremophilane-Type Sesquiterpene Derivatives from Senecio Culcitioides

Ist Teil von

• Natural product communications, 2012-04, Vol.7 (4), p.427-430

Ort / Verlag

Los Angeles, CA: SAGE Publications

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Four new eremophilane-type sesquiterpenes, culcitiolides A-D, were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor κB (NF-κB). Culcitiolides C and D at 20 μM showed 97 and 100% inhibition of NF-κB activity, respectively.