Organic & biomolecular chemistry, 2012-06, Vol.10 (21), p.4159-4163
2012
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Details
- Autor(en) / Beteiligte
- Titel
- Stereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from corals
- Ist Teil von
- Organic & biomolecular chemistry, 2012-06, Vol.10 (21), p.4159-4163
- Ort / Verlag
- England
- Erscheinungsjahr
- 2012
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A stereoselective synthesis of (25S)-Δ(1)-, (25S)-Δ(1,4)-, (25S)-Δ(1,7)-, (25S)-Δ(8(14))-, (25S)-Δ(4,6,8(14))-dafachronic acid, methyl (25S)-Δ(1,4)-dafachronate and (25S)-5α-hydroxy-3,6-dioxocholest-7-en-26-oic acid is described. (25S)-Δ(1,4)-Dafachronic acid and its methyl ester are natural products isolated from corals and have been obtained by synthesis for the first time. (25S)-5α-Hydroxy-3,6-dioxocholest-7-en-26-oic acid represents a promising synthetic precursor for cytotoxic marine steroids.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1477-0520eISSN: 1477-0539DOI: 10.1039/c2ob25394aTitel-ID: cdi_proquest_miscellaneous_1012207656
- Format
- –
- Schlagworte
- Animals, Anthozoa - chemistry, Caenorhabditis elegans - drug effects, Caenorhabditis elegans - genetics, Caenorhabditis elegans - growth & development, Caenorhabditis elegans Proteins - genetics, Cholestenes - chemical synthesis, Cholestenes - pharmacology, Dose-Response Relationship, Drug, Esters - chemical synthesis, Esters - pharmacology, Larva - drug effects, Larva - genetics, Larva - growth & development, Molecular Structure, Receptors, Cytoplasmic and Nuclear - deficiency, Receptors, Cytoplasmic and Nuclear - genetics, Stereoisomerism, Structure-Activity Relationship