Details

Autor(en) / Beteiligte

• Vidimliski, P D
• Andreevska, G S
• Pavlevska, S
• Trajceska, L
• Selim, G
• Gelev, S
• Amitov, V
• Sikole, A

Titel

SURVIVAL OF HEMODIALYSIS PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION

Ist Teil von

• International journal of artificial organs, 2011-08, Vol.34 (8), p.673-673

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objectives: The impact of hepatitis C virus (HCV) infection on mortality of hemodialysis patients remains controversial. The aim of the study was to estimate the survival of HCV positive and HCV negative hemodialysis (HD) patients. Methods: We conducted a prospective study with 149 HD patients followed from 01 January 2003 till 31 December 2010. Patients' survival was estimated by the Kaplan-Meier method and compared by the log rank test. The Cox proportional hazards model was used to estimate the risk of death in HD patients with HCV infection. Results: Of the 149 patients, 80 (53.7%) patients were men. Mean age of patients was 59.3 plus or minus 13.8 years with mean dialysis duration of 34.1 plus or minus 23.5 months. Hepatitis C virus infection was presented in 26.2% (39/149) of the HD patients. HCV positive patients were characterized with significantly longer dialysis duration compared to HCV negative, (48.9 plus or minus 21.6 vs. 28.9 plus or minus 21.96 months, p=0.000). During the study, 50 (33.6%) patients died. Cardiovascular disease was the main cause of death in 64% (32/50) of the dialysis patients. Patient survival was 56.4% (22/39) for HCV positive and 70% (77/110) for HCV negative patients. Log rank statistics showed no significant difference in survival between HCV positive and negative patients, (log rank, p=0.150). By Cox regression analysis, after adjusting for age, gender, and dialysis duration, HCV positive patients were characterized with a 0.43-fold higher chance to die compared to those without HCV infection (HR = 0.43, 95% CI 0.22- 0.83, p=0.011) Conclusions: There was no significant difference between HCV positive and HCV negative patients in terms of survival, but HCV infection remains a relative risk for mortality in hemodialysis patients.