Developmental dynamics, 2012-05, Vol.241 (5), p.995-1007
2012
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- Autor(en) / Beteiligte
- Titel
- Myogenic waves and myogenic programs during Xenopus embryonic myogenesis
- Ist Teil von
- Developmental dynamics, 2012-05, Vol.241 (5), p.995-1007
- Ort / Verlag
- New York: Wiley-Liss, Inc
- Erscheinungsjahr
- 2012
- Quelle
- Wiley Blackwell Single Titles
- Beschreibungen/Notizen
- Background: Although Xenopus is a key model organism in developmental biology, little is known about the myotome formation in this species. Here, we assessed the expression of myogenic regulatory factors of the Myod family (MRFs) during embryonic development and revealed distinct MRF programs. Results: The expression pattern of each MRF during embryonic development highlights three successive myogenic waves. We showed that a first median and lateral myogenesis initiates before dermomyotome formation: the median cell population expresses Myf5, Myod, and Mrf4, whereas the lateral one expresses Myod, moderate levels of Myogenin and Mrf4. The second wave of myoblasts arising from the dermomyotome is characterized by the full MRF program expression, with high levels of Myogenin. The third wave is revealed by Myf5 expression in the myotome and could contribute to the formation of plurinucleated fibers at larval stages. Furthermore, Myf5‐ or Myod‐expressing anlagen are identified in craniofacial myogenesis. Conclusions: The first median and lateral myogenesis and their associated MRF programs have probably disappeared in mammals. However, some aspects of Xenopus myogenesis have been conserved such as the development of somitic muscles by successive myogenic waves and the existence of Myf5‐dependent and ‐independent lineages. Developmental Dynamics 241:995–1007, 2012. © 2012 Wiley Periodicals, Inc. Key findings: The expression pattern of each myogenic regulatory factor (MRF) during embryonic development highlights three successive myogenic waves in Xenopus somites. A first median and lateral myogenesis initiates before dermomyotome formation in Xenopus. Xenopus craniofacial myogenesis is characterized by the presence of Myf5‐ or Myod‐lineages.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1058-8388eISSN: 1097-0177DOI: 10.1002/dvdy.23780Titel-ID: cdi_proquest_miscellaneous_1002503484
- Format
- –
- Schlagworte
- Animals, dermomyotome, Gene Expression Regulation, Developmental, head muscles, Mrf4, Muscle Development - genetics, Muscle, Skeletal - embryology, Muscle, Skeletal - metabolism, Myf5, Myod, MyoD Protein - genetics, MyoD Protein - metabolism, myogenesis, Myogenic Regulatory Factor 5 - genetics, Myogenic Regulatory Factor 5 - metabolism, Myogenic Regulatory Factors - genetics, Myogenic Regulatory Factors - metabolism, Myogenin, Myogenin - genetics, Myogenin - metabolism, somites, Xenopus, Xenopus - embryology, Xenopus - genetics, Xenopus - metabolism, Xenopus Proteins - genetics, Xenopus Proteins - metabolism