Details

Autor(en) / Beteiligte

• Smee, Robert I
• Williams, Janet R
• De-loyde, Katie J
• Meagher, Nicola S
• Cohn, Richard

Titel

Medulloblastoma: Progress over time

Ist Teil von

• Journal of medical imaging and radiation oncology, 2012-04, Vol.56 (2), p.227-234

Ort / Verlag

Melbourne, Australia: Blackwell Publishing Asia

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Introduction: Medulloblastoma is the most common central nervous system tumour in children aged 0–4 years, with 75% of cases occurring in patients <16 years, and rare in adults. The intent of this audit is to review a single centre's experience and to compare outcomes with other centres' outcomes. Methods: This Ethics approved retrospective audit evaluates the paediatric population aged <16 years who received radiotherapy as their initial or salvage treatment at the Prince of Wales Hospital Cancer Centre between 1972 and 2007. The primary and secondary end‐points were progression‐free survival (PFS) and cancer‐specific survival (CSS), with comparisons made between patients treated before and after 1990, and the impact of high‐ and low‐risk disease. Results: There were 80 eligible patients, 78 who had radiotherapy at initial presentation, and 2 at the time of recurrence. Median age was 6.5 years, 52 were boys and 28 were girls. Seventy‐eight patients had a surgical procedure and ultimately received craniospinal radiotherapy. Of these 78 patients, 32 (40%) had a macroscopically complete resection. The 5‐year PFS was 69.7%. The 5‐year PFS for patients treated pre and post 1990 was 66.1% and 71.8%, respectively. The 5‐year CSS for high‐ and low‐risk patients was 61.1% and 78.4%, respectively. Ultimately, 33% of patients were dead due to disease. Conclusion: This audit demonstrates those children referred to this facility for treatment have comparable survival to that of other major centres.