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Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia
Ist Teil von
Supportive care in cancer, 2012-05, Vol.20 (5), p.1101-1107
Ort / Verlag
Berlin/Heidelberg: Springer-Verlag
Erscheinungsjahr
2012
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background
Oral mucositis is a common collateral effect among the secondary complications resulting from chemotherapy. The objective of this study was to prospectively evaluate the association of
HSV-1
,
Candida
spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia (ALL).
Procedure
Seventy-one prospective patients were included. Analyses of oral microbiota were conducted on days 14 (D14) and 56 (D56) of the Brazilian GBTLI-99 treatment protocol.
Herpes simplex
virus (
HSV
) identification was performed by PCR followed by DNA sequencing analysis. Bacteria and fungi identification was obtained by standard microbiological culture tests.
Results
HSV-1
was found in 10.37% of individual patient samples. One sample was positive for
HSV-4
. On D14, we found an association between the severity of mucositis and the presence of
HSV
(
p =
0.0347) and
Candida
spp. (
p
= 0.0078). At D56, we found an association between the severity of mucositis and the presence of
HSV
on D14 (
p
< 0.0001) and
HSV
presence (
p =
0.0317).
Conclusion
The presence of
HSV
, mainly
HSV-1
, and
Candida
spp. was associated with mucositis severity in pediatric ALL. No association could be found between bacterial CFU and severity of mucositis.