Details

Autor(en) / Beteiligte

• Novoselov, V. I.
• Ravin, V. K.
• Sharapov, M. G.
• Sofin, A. D.
• Kukushkin, N. I.
• Fesenko, E. E.

Titel

Modified peroxiredoxins as prototypes of drugs with powerful antioxidant action

Ist Teil von

• Biophysics (Oxford), 2011-10, Vol.56 (5), p.836-842

Ort / Verlag

Dordrecht: SP MAIK Nauka/Interperiodica

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The possibility of using modified peroxiredoxins as powerful antioxidant agents has been considered. Peroxiredoxins immobilized on perfluorocarbon emulsions and PTD-modified peroxiredoxins have been studied. It has been shown that peroxiredoxins efficiently bind to particles of perfluorocarbon emulsions, while maintaining their antioxidant properties. A panel of PTD-modified peroxiredoxins has been created and peroxiredoxins most effective both in antioxidant properties and the ability to penetrate cells have been selected. The modified peroxiredoxins obtained may serve as the basis for the design of drug with powerful antioxidant action.