Details

Autor(en) / Beteiligte

• KANONI, Stavroula
• NETTLETON, JenniferA
• GUSTAFSSON, Stefan
• ANDERSON, Jennifer S
• TANAKA, Toshiko
• HINDY, George
• SAYLOR, Georgia
• RENSTROM, Frida
• BENNETT, Amanda J
• VAN DUIJN, Cornelia M
• FLOREZ, Jose C
• FOX, Caroline S
• HIVERT, Marie-France
• HOFMAN, Albert
• HOOGEVEEN, Ron C
• HOUSTON, Denise K
• HU, Frank B
• JACQUES, Paul F
• JOHANSSON, Ingegerd
• LIND, Lars
• LIU, Yongmei
• MCKEOWN, Nicola
• ORDOVAS, Jose
• ZHENGYE
• PANKOW, James S
• SIJBRANDS, Eric J. G
• SYVÄNEN, Ann-Christine
• UITTERLINDEN, André G
• YANNAKOULIA, Mary
• CAROLA ZILLIKENS, M
• WAREHAM, Nick J
• PROKOPENKO, Inga
• BANDINELLI, Stefania
• FOROUHI, Nita G
• VAN ROOIJ, Frank J. A
• ADRIENNE CUPPLES, L
• LOOS, Ruth J
• HALLMANS, Goran
• DUPUIS, Josee
• LANGENBERG, Claudia
• FERRUCCI, Luigi
• KRITCHEVSKY, Stephen B
• MCCARTHY, Mark I
• INGELSSON, Erik
• BORECKI, Ingrid B
• SHUNGIN, Dmitry
• WITTEMAN, Jacqueline C. M
• ORHO-MELANDER, Marju
• SISCOVICK, David S
• MEIGS, James B
• FRANKS, Paul W
• DEDOUSSIS, George V
• SONESTEDT, Emily
• NGWA, JuliusS
• WOJCZYNSKI, Mary K
• LEMAITRE, Rozenn N

Titel

Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort Meta-analysis

Ist Teil von

• Diabetes (New York, N.Y.), 2011-09, Vol.60 (9), p.2407-2416

Ort / Verlag

Alexandria, VA: American Diabetes Association

Erscheinungsjahr

2011

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants. We conducted a 14-cohort meta-analysis to assess the interaction of 20 genetic variants known to be related to glycemic traits and zinc metabolism with dietary zinc intake (food sources) and a 5-cohort meta-analysis to assess the interaction with total zinc intake (food sources and supplements) on fasting glucose levels among individuals of European ancestry without diabetes. We observed a significant association of total zinc intake with lower fasting glucose levels (β-coefficient ± SE per 1 mg/day of zinc intake: -0.0012 ± 0.0003 mmol/L, summary P value = 0.0003), while the association of dietary zinc intake was not significant. We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: -0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it. None of the other interaction tests were statistically significant. Our results suggest that higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Our findings also support evidence for the association of higher total zinc intake with lower fasting glucose levels.