Details

Autor(en) / Beteiligte

• Marcocci, Claudio
• Cetani, Filomena

Titel

Primary Hyperparathyroidism

Ist Teil von

• The New England journal of medicine, 2011-12, Vol.365 (25), p.2389-2397

Ort / Verlag

Waltham, MA: Massachusetts Medical Society

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• This article reviews the differential diagnosis and management of primary hyperparathyroidism. For most patients, parathyroidectomy (usually by a minimally invasive approach) is recommended, but surveillance is an option for asymptomatic patients who meet certain criteria. Foreword This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations. Stage A 62-year-old woman is found on routine laboratory testing to have a serum calcium level of 10.8 mg per deciliter (2.7 mmol per liter) (normal range, 8.4 to 10.4 [2.1 to 2.7]). The serum intact parathyroid hormone (PTH) concentration is 70 pg per milliliter (normal range, 15 to 75). Her history is notable only for hypertension that is well controlled with an angiotensin-receptor blocker; there is no history of kidney stones or fractures. Her family history is negative for hypercalcemia or endocrine tumors. Her 24-hour urinary calcium and creatinine levels are 280 mg and 1050 mg, respectively, and the ratio . . .