Details

Autor(en) / Beteiligte

• Rahman, Najib M
• Maskell, Nicholas A
• West, Alex
• Teoh, Richard
• Arnold, Anthony
• Mackinlay, Carolyn
• Peckham, Daniel
• Davies, Robert J.O
• Davies, Chris W.H
• Davies, Helen E
• Ali, Nabeel
• Kinnear, William
• Bentley, Andrew
• Kahan, Brennan C
• Wrightson, John M
• Hooper, Clare E
• Lee, Y.C. Gary
• Hedley, Emma L
• Crosthwaite, Nicky
• Choo, Louise
• Helm, Emma J
• Gleeson, Fergus V
• Nunn, Andrew J

Titel

Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection

Ist Teil von

• The New England journal of medicine, 2011-08, Vol.365 (6), p.518-526

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2011

Quelle

MEDLINE

Beschreibungen/Notizen

• Slowly clearing infections in the pleural space are a source of substantial morbidity. This study showed that instillation of recombinant DNase and tissue plasminogen activator (t-PA) is more effective than placebo in clearing radiographic pleural effusions. Pleural infection affects more than 65,000 patients each year in the United States and the United Kingdom, 1 and the incidence is increasing in both countries — in both children 2 – 4 and adults. 5 , 6 The mortality rate from pleural infection is between 10% and 20%, 5 , 7 – 9 and drainage through a chest tube and administration of antibiotics fail in approximately one third of patients, who then require surgical drainage. 5 , 9 The median duration of the hospital stay for these patients is 12 to 15 days, 5 , 6 , 8 , 9 with 25% hospitalized for more than a month. Care of each patient costs . . .