Details

Autor(en) / Beteiligte

• Stevenson, Donald D.

Titel

Aspirin sensitivity and desensitization for asthma and sinusitis

Ist Teil von

• Current allergy and asthma reports, 2009-03, Vol.9 (2), p.155-163

Ort / Verlag

New York: Current Science Inc

Erscheinungsjahr

2009

Quelle

SpringerLink

Beschreibungen/Notizen

• NSAIDs—including aspirin (ASA)—that inhibit cyclooxygenase (COX)-1 induce nonallergic hypersensitivity reactions consisting of attacks of rhinitis and asthma. Such reactions occur exclusively in a subset of asthmatic patients who also have underlying nasal polyps and chronic hyperplastic eosinophilic sinusitis. We now refer to their underlying inflammatory disease of the entire respiratory tract as aspirin-exacerbated respiratory disease . This review focuses on descriptions of these patients; methods available to diagnose ASA-exacerbated respiratory disease; the unique ability of all NSAIDs that inhibit COX-1 to cross-react with ASA; lack of cross-reactivity with selective COX-2 inhibitors; an update on pathogenesis; and current thoughts about treatment, including ASA desensitization and daily ingestion of ASA itself.