Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11644-11649
2011
Details
- Autor(en) / Beteiligte
- Titel
- Taste-independent detection of the caloric content of sugar in Drosophila
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11644-11649
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Feeding behavior is influenced primarily by two factors: nutritional needs and food palatability. However, the role of food deprivation and metabolic needs in the selection of appropriate food is poorly understood. Here, we show that the fruit fly, Drosophila melanogaster, selects calorie-rich foods following prolonged food deprivation in the absence of taste-receptor signaling. Flies mutant for the sugar receptors Gr5a and Gr64a cannot detect the taste of sugar, but still consumed sugar over plain agar after 15 h of starvation. Similarly, pox-neuro mutants that are insensitive to the taste of sugar preferentially consumed sugar over plain agar upon starvation. Moreover, when given a choice between metabolizable sugar (sucrose or D-glucose) and nonmetabolizable (zero-calorie) sugar (sucralose or L-glucose), starved Gr5a; Gr64a double mutants preferred metabolizable sugars. These findings suggest the existence of a taste-independent metabolic sensor that functions in food selection. The preference for calorie-rich food correlates with a decrease in the two main hemolymph sugars, trehalose and glucose, and in glycogen stores, indicating that this sensor is triggered when the internal energy sources are depleted. Thus, the need to replenish depleted energy stores during periods of starvation may be met through the activity of a taste-independent metabolic sensing pathway.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.1017096108Titel-ID: cdi_proquest_journals_877025416
- Format
- –
- Schlagworte
- Agar, Animal behavior, Animals, Biological Sciences, Carbohydrate Metabolism, Dietary restrictions, Dietary Sucrose, Drosophila, Drosophila melanogaster, Drosophila melanogaster - genetics, Drosophila melanogaster - physiology, Drosophila Proteins - genetics, Drosophila Proteins - physiology, Energy, energy content, Energy Intake, Energy sources, Feeding behavior, Feeding Behavior - physiology, Food, food choices, Food deprivation, Food Deprivation - physiology, Food preferences, Food Preferences - physiology, Food selection, fruit flies, fruits, Genes, Insect, Glucose, Glycogen, Gustatory perception, Hemolymph, Hemolymph - metabolism, Insects, Male, Metabolism, Mutants, Mutation, Neurons, Nutrition, Palatability, plains, Receptors, Receptors, Cell Surface - genetics, Receptors, Cell Surface - physiology, Sensors, Signal transduction, Starvation, Starvation - genetics, Starvation - physiopathology, sucralose, Sucrose, Sugar, Sugars, Taste, Taste - physiology, taste receptors, Trehalose