Details

Autor(en) / Beteiligte

• Holloway, Cameron J
• Cochlin, Lowri E
• Emmanuel, Yaso
• Murray, Andrew
• Codreanu, Ion
• Edwards, Lindsay M
• Szmigielski, Cezary
• Tyler, Damian J
• Knight, Nicholas S
• Saxby, Brian K
• Lambert, Bridget
• Thompson, Campbell
• Neubauer, Stefan
• Clarke, Kieran

Titel

A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects

Ist Teil von

• The American journal of clinical nutrition, 2011-04, Vol.93 (4), p.748-755

Ort / Verlag

Bethesda, MD: Elsevier Inc

Erscheinungsjahr

2011

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background: High-fat, low-carbohydrate diets are widely used for weight reduction, but they may also have detrimental effects via increased circulating free fatty acid concentrations. Objective: We tested whether raising plasma free fatty acids by using a high-fat, low-carbohydrate diet results in alterations in heart and brain in healthy subjects. Design: Men (n = 16) aged 22 ± 1 y (mean ± SE) were randomly assigned to 5 d of a high-fat, low-carbohydrate diet containing 75 ± 1% of calorie intake through fat consumption or to an isocaloric standard diet providing 23 ± 1% of calorie intake as fat. In a crossover design, subjects undertook the alternate diet after a 2-wk washout period, with results compared after the diet periods. Cardiac 31P magnetic resonance (MR) spectroscopy and MR imaging, echocardiography, and computerized cognitive tests were used to assess cardiac phosphocreatine (PCr)/ATP, cardiac function, and cognitive function, respectively. Results: Compared with the standard diet, subjects who consumed the high-fat, low-carbohydrate diet had 44% higher plasma free fatty acids (P < 0.05), 9% lower cardiac PCr/ATP (P < 0.01), and no change in cardiac function. Cognitive tests showed impaired attention (P < 0.01), speed (P < 0.001), and mood (P < 0.01) after the high-fat, low-carbohydrate diet. Conclusion: Raising plasma free fatty acids decreased myocardial PCr/ATP and reduced cognition, which suggests that a high-fat diet is detrimental to heart and brain in healthy subjects.