Details

Autor(en) / Beteiligte

• Fu, Ru-huei
• Hran, Horng-jyh
• Chu, Ching-liang
• Huang, Chin-mao
• Liu, Shih-ping
• Wang, Yu-chi
• Lin, Ya-hsien
• Shyu, Woei-cherng
• Lin, Shinn-zong

Titel

Lipopolysaccharide-stimulated activation of murine DC2.4 cells is attenuated by n-butylidenephthalide through suppression of the NF-[kappa]B pathway

Ist Teil von

• Biotechnology letters, 2011-05, Vol.33 (5), p.903

Ort / Verlag

Dordrecht: Springer Nature B.V

Erscheinungsjahr

2011

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Modulation of dendritic cell (DC) fate and function may be one approach for the treatment of inflammatory and autoimmune diseases. n-Butylidenephthalide (BP), derived from Angelica sinensis, at 40 μg/ml significantly decreased the secretion of interleukin-6 and tumor necrosis factor-α by lipopolysaccharide (LPS)-stimulated activation of cultured murine DC2.4 cells (P < 0.01). LPS-induced major histocompatibility complex class II (P < 0.05), CD86 (P < 0.01) and CD40 (P < 0.01) expression on DC2.4 cells was also inhibited by BP. The endocytic capacity of LPS-stimulated DC2.4 cells was increased by BP (P < 0.01). The antigen-presenting capacity of LPS-stimulated DC2.4 cells was decreased by BP (P < 0.05). Moreover, we confirmed BP attenuates the responses of LPS-stimulated activation of DCs via suppression of NF-κB-dependent pathways.[PUBLICATION ABSTRACT]