Details

Autor(en) / Beteiligte

• Elsässer, Simon J.
• Allis, C. David
• Lewis, Peter W.

Titel

New Epigenetic Drivers of Cancers

Ist Teil von

• Science (American Association for the Advancement of Science), 2011-03, Vol.331 (6021), p.1145-1146

Ort / Verlag

Washington: American Association for the Advancement of Science

Erscheinungsjahr

2011

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Mutations in proteins that control chromatin dynamics contribute to tumorigenesis. Exome sequencing—the targeted sequencing of all protein-coding regions in the human genome—now offers an unprecedented opportunity for systematic, genome-wide discovery of somatic mutations in tumor tissue. On page 1199 of this issue, Jiao et al. ( 1 ) have applied this pioneering technique to identify common genetic mutations underlying pancreatic neuroendocrine tumors (PanNETs), a class of tumors that frequently arise from pancreatic islet cells. This report adds to a growing number of studies that use exome sequencing to explore cancers with unknown or poorly understood genetic etiology ( 2 – 8 ).