Details

Autor(en) / Beteiligte

• Liapi, Eleni
• Geschwind, Jean-Francois H
• Vali, Mustafa
• Khwaja, Afsheen A
• Prieto-Ventura, Veronica
• Buijs, Manon
• Vossen, Josephina A
• Ganapathy, Shanmugasudaram
• Wahl, Richard L

Titel

Assessment of Tumoricidal Efficacy and Response to Treatment with ^sup 18^F-FDG PET/CT After Intraarterial Infusion with the Antiglycolytic Agent 3-Bromopyruvate in the VX2 Model of Liver Tumor

Ist Teil von

• The Journal of nuclear medicine (1978), 2011-02, Vol.52 (2), p.225

Ort / Verlag

New York: Society of Nuclear Medicine

Erscheinungsjahr

2011

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The purpose of this study was to determine the effects of 3-bromopyruvate (3-BrPA) on tumor glucose metabolism as imaged with ^sup 18^F-FDG PET/CT at multiple time points after treatment and compare them with those after intraarterial control injections of saline. Methods: Twenty-three New Zealand White rabbits implanted intrahepatically with VX2 tumors were assigned to 1 of 2 groups: 14 rabbits were assigned to the treatment group (TG) and 9 to the saline control group (SG). All animals were infused with 25 mL of either 1.75 mM 3-BrPA or saline over 1 h via a 2-French catheter, which was secured in the hepatic artery. For PET/CT, the animals were injected with 37 MBq of ^sup 18^F-FDG at 1 d before treatment and 2 h, 24 h, and 1 wk after treatment. Tumor size, tumor and liver maximal standardized uptake value (SUV^sub max^), and tumor-to-background ratios were calculated for all studies. Seven TG and 5 SG animals were sacrificed at 1 wk after treatment for histopathologic analysis. Results: Intense ^sup 18^F-FDG uptake was seen in untreated tumors. A significant reduction in tumor SUV^sub max^ was noted in TG animals, when compared with SG animals, at 1 wk after treatment (P = 0.006). The tumor-to-liver background ratio in the TG animals, compared with the SG animals, was significantly reduced as early as 24 h after treatment (P = 0.01) and remained reduced at 1 wk (P = 0.003). Tumor SUV^sub max^ increased from the baseline levels at 7 d in controls (P = 0.05). The histopathologic analysis of explanted livers revealed increased tumor necrosis in all TG samples. There was a significant inverse correlation (r^sup 2^ = 0.538, P = 0.005) between the percentage of tumor necrosis on histopathology and tumor SUV^sub max^ on ^sup 18^F-FDG PET at 7 d after treatment with 3-BrPA. Conclusion: Intraarterial injection of 3-BrPA resulted in markedly decreased ^sup 18^F-FDG uptake as imaged by PET/CT and increased tumor necrosis on histopathology at 1 wk after treatment in the VX2 rabbit liver tumor. PET/CT appears to be a useful means to follow antiglycolytic therapy with 3-BrPA. [PUBLICATION ABSTRACT]