Nature medicine, 2011-02, Vol.17 (2), p.164-165
2011
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Details
- Autor(en) / Beteiligte
- Titel
- Linking the inflammasome to obesity-related disease
- Ist Teil von
- Nature medicine, 2011-02, Vol.17 (2), p.164-165
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chronic inflammation is associated with obesity, but the pathways that mediate this phenomenon are not fully characterized. The nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (Nlrp3) inflammasome functions as a sensor to detect danger signals and induce downstream inflammatory signaling that contributes to obesity-associated conditions such as insulin resistance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956eISSN: 1546-170XDOI: 10.1038/nm0211-164Titel-ID: cdi_proquest_journals_849502353
- Format
- –
- Schlagworte
- Animals, Cellular biology, Complications and side effects, Disease Models, Animal, Humans, Inflammasomes - metabolism, Inflammasomes - physiology, Inflammation, Inflammation - metabolism, Inflammation - physiopathology, Inflammatory diseases, Insulin resistance, Insulin Resistance - physiology, Interleukins, Mice, Obesity, Obesity - metabolism, Obesity - physiopathology, Physiological aspects, Risk factors, Signal transduction