Details

Autor(en) / Beteiligte

• Levin, S. G.
• Godukhin, O. V.

Titel

The Role of High-Conductivity Ca2+-Activated Potassium Channels in the Preconditioning Effects of Hypoxia and Posthypoxic Hyperexcitability of Neurons in Hippocampal Field CA1 in Vitro

Ist Teil von

• Neuroscience and behavioral physiology, 2010-11, Vol.40 (9), p.969-974

Ort / Verlag

Boston: Springer US

Erscheinungsjahr

2010

Quelle

SpringerLink Journals - AutoHoldings

Beschreibungen/Notizen

• The effects of the specific high-conductivity Ca 2+ -activated potassium channel blocker iberiotoxin on processes induced in rat hippocampal field CA1 slices by transient episodes of hypoxia were studied, i.e., 1) the suppressing effect of hypoxia on pyramidal neuron activity during hypoxic episodes, 2) the preconditioning action of hypoxia, and 3) posthypoxic neuron hyperexcitability. These experiments showed that iberiotoxin (10–20 nM) produced a tendency to decreases in the effectiveness of hypoxic episodes in depressing the amplitudes of population spikes recorded in hippocampal field CA1 during hypoxia. The high-conductivity Ca 2+ -activated potassium channel blocker significantly decreased the preconditioning effects of the first two episodes of hypoxia on the ability of the third episode of hypoxia to suppress neuron activity. Iberiotoxin also suppressed the posthypoxic hyperexcitability of pyramidal neurons. It is suggested that high-conductivity Ca 2+ -activated potassium channels play an important role in the mechanisms of development of types of neuroplasticity induced by transient episodes of hypoxia such as rapid hypoxic preconditioning and posthypoxic hyperexcitability.