Details

Autor(en) / Beteiligte

• Ratajczak, M Z
• Kim, C H
• Wojakowski, W
• Janowska-Wieczorek, A
• Kucia, M
• Ratajczak, J

Titel

Innate immunity as orchestrator of stem cell mobilization

Ist Teil von

• Leukemia, 2010-10, Vol.24 (10), p.1667-1675

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Hematopoietic stem and progenitor cells (HSPCs), as well as other types of stem cells, circulate under steady-state conditions at detectable levels in peripheral blood (PB), with their numbers increasing in response to stress, inflammation and tissue/organ injury. This mobilization process may be envisioned as a danger-sensing response mechanism triggered by hypoxia or mechanical or infection-induced tissue damage that recruits into PB different types of stem cells that have a role in immune surveillance and organ/tissue regeneration. Mobilization is also significantly enhanced by the administration of pharmacological agents, which has been exploited in hematological transplantology as a means to obtain HSPCs for hematopoietic reconstitution. In this review we will present mounting evidence that innate immunity orchestrates this evolutionarily conserved mechanism of HSPC mobilization.