Details

Autor(en) / Beteiligte

• Bateneva, A.V
• Gamaley, S.G
• Danilenko, E.D
• Masycheva, V.I
• Lebedev, L.R
• Sysoeva, G.M

Titel

Pharmacokinetics and antitumor effects of the drug containing TNF-[alpha] in nanoparticles

Ist Teil von

• Bulletin of experimental biology and medicine, 2010-09, Vol.149 (3), p.320

Ort / Verlag

New York: Springer

Erscheinungsjahr

2010

Quelle

SpringerLink

Beschreibungen/Notizen

• Antitumor activity of TNF-[alpha] incorporated in nanoparticles (VLP-TNF-[alpha]) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-[alpha] preparation exhibited higher antitumor activity compared to free TNF-[alpha], presumably due to longer circulation of the cytokine in the blood and its more intensive accumulation by tumor tissue. Key Words: tumor necrosis factor-[alpha]; double-strand RNA; nanoparticle; pharmacokinetics; Ehrlich carcinoma