Details

Autor(en) / Beteiligte

• Kadiyani, Lamk
• Kalaivani, Mani
• Iyer, Krishna S
• Ramakrishnan, Sivasubramanian

Titel

The outcome of surgery for congenital heart disease in India: A systematic review and metanalysis

Ist Teil von

• Annals of pediatric cardiology, 2024-05, Vol.17 (3), p.164-179

Ort / Verlag

Mumbai: Medknow Publications and Media Pvt. Ltd

Erscheinungsjahr

2024

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• ABSTRACT Background: The mortality risks of children undergoing various cardiac surgeries for congenital heart disease (CHD) in India are not well defined. We conducted a systematic review and meta-analysis to estimate the inhospital mortality of various common CHD surgeries reported in India and compared it to representative data from established Western databases. Methods and Results: We searched four bibliographic databases for studies published in India over the last 25 years. In total, 135 studies met the inclusion criteria and included 30,587 patients aged from 1 day to 65 years. The pooled mortality rate of 43 Indian studies reporting multiple CHD surgical outcomes is 5.63 (95 confidence interval [CI]: 4.26-7.16; I[sup.2] = 93.9), whereas the Western data showed a pooled mortality rate of 2.65 (P value for comparison <0.0001). The pooled mortality risk for ventricular septal defect closure and tetralogy of Fallot repair in Indian studies was 2.87 (95 CI: 0.76-5.91; I[sup.2] = 62.4) and 4.61 (95 CI: 2.0-8.02; I[sup.2] = 87.4), respectively. The estimated mortality risk was higher than the Western databases for all subcategories studied except for surgeries in the grown-ups with CHD population and coarctation repair. Conclusions: The estimated mortality risks are higher among Indian patients undergoing cardiac surgery for CHD as compared to Western data. We need prospective multicentric data to document whether the observed excess mortality exists after adjusting for various high-risk features and comorbidities in Indian patients. We need systemic measures to improve the outcomes of CHD surgeries in India. Keywords: Operative mortality, low- and middle-income countries, pooled mortality risk, congenital heart surgery