Details

Autor(en) / Beteiligte

• Enríquez, Rodrigo G.
• Dato-Santiago, Juan S.
• del Río-Rodríguez, Roberto
• Alemán, José
• Fernández-Salas, Jose A.

Titel

Acyl radicals generated from aldehydes with NHPI as electrocatalyst: aldehydes and alcohols as carbon-centered radical precursors

Ist Teil von

• Organic Chemistry Frontiers, 2024-08, Vol.11 (17), p.4842-4848

Ort / Verlag

London: Royal Society of Chemistry

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this work, we describe how N -hydroxyphthalimide (NHPI) promotes hydrogen atom transfer from aldehydes under electrocatalytic chemical conditions. This involves the generation of phthalimide- N -oxyl (PINO), which abstracts an acyl hydrogen to produce acyl radicals from aldehydes. These acyl radicals then react with oximes or another PINO radical to form redox-active esters (RAEs). Additionally, we detail a Giese-type reaction with electron-deficient alkenes via electrochemical reduction of the generated RAE derivatives. This process produces sp 3 -carbon centered radicals from aldehydes. We also extend this method to aliphatic alcohols, involving a multi-step electrochemical process to form carbon-centered radicals from readily available alcohols.