Details

Autor(en) / Beteiligte

• Cutteridge, Joseph
• Gowri, Mahasampath
• Antonisamy, B
• Vasan, Senthil

Titel

Association Between Birthweight and Adult Central Obesity: Evidence in Asian Indians

Ist Teil von

• Obesity (Silver Spring, Md.), 2023-11, Vol.31, p.232-232

Ort / Verlag

Silver Spring: Blackwell Publishing Ltd

Erscheinungsjahr

2023

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Background: Central obesity is one of the key risk factors for the development of cardiovascular disease (CVD). Low birthweight (BW) and greater childhood weight gain have been associated with central obesity in adulthood. We examined whether BW is an independent risk factor for the development of central obesity and other CVD risk factors in Asan Indians, who are known to develop CVD at a younger age. Methods: BW data were collected from 1360 individuals born in Vellore, Southern India, between 1969 and 1973. Association between adult CVD risk factors and BW stratified into low (BW<2.5 kg), normal (2.5 < BW <3.5), and high (BW>3.5) were assessed using linear and logistic regression models adjusted for potential confounders. Results: The mean (SD) adult age was 46 years (1.0). LBW was significantly associated with the development of central obesity (OR 1.68, 95%CI 1.18-2.37, p-value 0.004). Furthermore, LBW was associated with increases in specific body fat components: android fat mass (þ 0.03, 95%CI 0.00-0.05, p-value 0.023) and visceral fat mas (jb 0.06, 95%CI 0.02-0.10, p-value 0.005) as well as increased total fat percentage (þ 0.02, 95%CI 0.01-0.04, p-value 0.001) and total fat index (þ 0.02, 95%CI 0.00-0.04, p-value 0.016). HBW individuals had a healthier body composition, characterized by greater lean mass, and reduced total fat index. LBW was associated with an increased risk of diabetes (OR 1.39, 95%CI 1.03-1.87, p-value 0.029), whilst HBW individuals had a reduced risk hypertension (OR 0.52, 95%CI 0.320.85, p-value 0.008) and better glycaemic control. Conclusions: Asian Indians born at lower BW are at greater risk of developing central obesity and other CVD risk factors such as diabetes, when compared with their normal birthweight counterparts. Early interventions that aim to improve maternal nutrition could positively impact the birth weight of the child and reduce the risk of developing CVD in adulthood.