Details

Autor(en) / Beteiligte

• Yosif, Hadeel M.
• Hasoon, Buthenia A.
• Jabir, Majid S.

Titel

Laser Ablation for Synthesis of Hydroxyapatite and Au NP Conjugated Cefuroxime: Evaluation of Their Effects on the Biofilm Formation of Multidrug Resistance Klebsiella pneumoniae

Ist Teil von

• Plasmonics (Norwell, Mass.), 2024-06, Vol.19 (3), p.1085-1099

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In this study, pulsed laser ablation was utilized to produce gold nanoparticles (Au NPs), hydroxyapatite NPs, and then conjugated with cefuroxime as a heteronanocomposite structure targeting Klebsiella pneumoniae . When Klebsiella forms a biofilm, it shows a remarkable resistance against a variety of antibiotics. The heterostructure nanocomposite was characterized using UV/Vis spectrophotometry, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). The antibacterial activity of the heteronanocomposite against Klebsiella pneumoniae was assessed and compared with the cefuroxime alone. The inhibitory action of the heteronanocomposite of biofilm in the urinary catheter (Foley’s catheter) was examined by atomic force microscopy (AFM). The results of the current study demonstrated that the heteronanocomposite had antimicrobial activity greater than cefuroxime alone to stop the growth of microbial biofilms. This heteronanocomposite has shown a promising result, which could be a reliable therapy against Klebsiella pneumoniae in the future and could be a promising agent for succeeding bacterial biofilm inhibition during a urinary tract infection.