Details

Autor(en) / Beteiligte

• Han, Changhong
• Yang, Lu
• Yao, Kaizong
• Zhang, Sen
• Fu, Jiayue
• Sun, Hanyang
• Xu, Hongsheng
• Lin, Bin
• Cheng, Maosheng
• Liu, Yongxiang

Titel

Asymmetric Synthesis of Dihydrospirotryprostatin B via a Silica Gel‐Mediated Cyclization of Tryptamine‐Ynamide

Ist Teil von

• Chinese journal of chemistry, 2024-06, Vol.42 (12), p.1355-1359

Ort / Verlag

Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA

Erscheinungsjahr

2024

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Comprehensive Summary An asymmetric synthesis of dihydrospirotryprostatin B was achieved in 15 steps (8 purifications) from L‐tryptophan. The main feature of our synthetic strategy is the efficient construction of spirocyclic oxindole intermediate containing a chiral quaternary carbon center, involving the silica gel‐mediated cyclization of tryptamine‐ynamide and oxidation under neat conditions. An asymmetric synthesis of dihydrospirotryprostatin B was achieved through silica gel‐mediated cyclization of tryptamine‐ynamide based on a chiral pool strategy.