Details

Autor(en) / Beteiligte

• Fan, Yu-Wen
• Ao, Zhuo-Yi
• Zhang, Wei-Jie
• Chen, Jia-Yan
• Lian, Xin
• Chen Pan, Yong
• Chen, Li-Ping
• Wu, Jie-Wei
• Yuan, Jie

Titel

The sesquiterpenes with the COVID-19 Mpro inhibitory activity from the Carpesium abrotanoides L

Ist Teil von

• Natural product research, 2024-06, Vol.38 (11), p.1909-1917

Ort / Verlag

Abingdon: Taylor & Francis

Erscheinungsjahr

2024

Quelle

Taylor & Francis

Beschreibungen/Notizen

• The extract of the whole plant of Carpesium abrotanoides L. yielded four new sesquiterpenes including a novel skeleton (claroguaiane A, 1), two guaianolides (claroguaianes B-C, 2-3), and one eudesmanolide (claroeudesmane A, 4), together with three known sesquiterpenoids (5-7). The structures of the new compounds were elucidated by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data. Additionally, all the isolated compounds were preliminarily evaluated for the inhibitive activity of COVID-19 M pro . As a result, compound 5 showed moderate activity with an IC 50 value of 36.81 μM and compound 6 exhibited a potent inhibitory effect with an IC 50 value of 16.58 µM, while other compounds were devoid of noticeable activity (IC 50  > 50 μM).