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Estudio de las propiedades fisicoquímicas del pindolol y de sus complejos de inclusión con ciclodextrinas. Retención en polímeros insolubles de ciclodextrina
Ort / Verlag
ProQuest Dissertations & Theses
Erscheinungsjahr
2004
Link zum Volltext
Quelle
ProQuest Dissertations & Theses A&I
Beschreibungen/Notizen
Pindolol [1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol] is a noncardioselective beta blocker commonly used in the treatment of cardiovascular disorders. The spectrofluorimetric characteristics of pindolol such as sensibility, detection limits and fluorescence quantum yields have been investigated in different solvents with the aim of using this technique for analytical determinations. It has been found that the fluorimetric analysis of pindolol is improved in the presence of cyclodextrins. Other monosubstituted indole derivatives, 4-methoxy and 5-methoxyindole have been also studied for comparative purposes. In addition, the formation of inclusion complexes of these compounds with cyclodextrins has been studied. Complexation with cyclodextrins has been widely used to improve the solubility, bioavailability and stability of pharmaceuticals. The complexation has been evidenced using different techniques such as fluorimetric and spectrophotometric measurements, liquid chromatography (HPLC), solubility isotherms, nuclear magnetic resonance (1H-NMR) and molecular dynamic simulations. The thermodynamic parameters associated to the complexation of pindolol with β, hydroxypropil-β- and methyl-β-cyclodextrin have been determined as well. Finally, crosslinked polymers containing β-cyclodextrin units have been used to remove pindolol, propranolol and other indole derivatives from aqueous solutions close to their saturation concentrations. The temperature dependent behaviour of the compounds analysed shows significant differences, attributable both to the influence of the polarity of their substituents and to the heterogeneity of the sorbent, since the cyclodextrin cavity sites are more favourable for interaction with the sorbate molecules than the crosslinking network.