Details

Autor(en) / Beteiligte

• Tang, Xiaohui
• Zhang, Qian
• Aikelamu, Kadireya
• Bai, Jingya
• Ma, Rong
• Wang, Mei
• Liu, Chao

Titel

Effect of quaternized chitosan magnetic nanoparticles carrying indocyanine green phototherapy on cervical cancer cells

Ist Teil von

• Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2024-05, Vol.26 (5), p.89

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The objective of the study is to prepare quaternized chitosan magnetic nanoparticles (ICG@Fe 3 O 4 @QCS) loaded with indocyanine green and to investigate their properties. Fe 3 O 4 @QCS nanoparticles were prepared by a one-part precipitation method and evaluated for their structure, particle size, morphology, and magnetic responsiveness. ICG@Fe 3 O 4 @QCS nanoparticles were prepared by electrostatic adsorption to investigate the properties of ICG@Fe 3 O 4 @QCS nanoparticles, such as particle size, zeta potential, encapsulation rate, drug loading, stability, photo- and thermo-conversion efficiencies, degree of release, biosafety, and in vitro antitumor property. Fe 3 O 4 @QCS nanoparticles were successfully prepared in the form of short rods with particle sizes around 20–30 nm, positively charged, with basic Fe 3 O 4 skeleton, and possessing specific magnetic responsiveness. ICG@Fe 3 O 4 @QCS nanoparticles were successfully prepared, particle size is around 100–150 nm, charged positively, the encapsulation rate is ≥ 90%, the drug loading is 0.05–2.00%, the release is slower compared with the ICG solution, and hemolysis rate is less than 2% in all cases; in the laser irradiation, the nanoparticles can produce ROS and thermal effects and have the function of NIR imaging. Antitumor experiments in vitro showed that ICG@Fe 3 O 4 @QCS nanoparticles had strong phototoxicity, had a particular killing effect on tumor cells, and could promote Hela cell apoptosis. ICG@Fe 3 O 4 @QCS nanoparticles can be successfully prepared by the electrostatic adsorption method, with the stable nature of ICG@Fe 3 O 4 @QCS nanoparticles, which can improve the bioavailability of ICG, and the prepared nanoparticles have good antitumor properties.