Details

Autor(en) / Beteiligte

• Zhou, Hao
• Qian, Qiuping
• Chen, Qizhu
• Chen, Tao
• Wu, Chenyu
• Chen, Linjie
• Zhang, Zhiguang
• Wu, Ouqiang
• Jin, Yuxin
• Wang, Xinzhou
• Guo, Zhenyu
• Sun, Jing
• Zhang, Jun
• Shen, Shuying
• Wang, Xiangyang
• Jones, Morgan
• Khan, Moonis Ali
• Makvandi, Pooyan
• Zhou, Yunlong
• Wu, Aimin

Titel

Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration (Small 13/2024)

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2024-03, Vol.20 (13), p.n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Intervertebral Disc Degeneration In article number 2308167, Pooyan Makvandi, Yunlong Zhou, Aimin Wu, and co‐workers prepared a multifunctional metal polyphenol nanoparticle that exhibited the ability to escape lysosomal capture and effectively targeted mitochondria to scavenge excess reactive oxygen species. The results of in vitro and in vivo experiments showed that the nanoparticles retarded disc degeneration by inhibiting Pyroptosis and maintaining the metabolic homeostasis of the extracellular matrix in the nucleus pulposus.