Natural products and bioprospecting, 2024-12, Vol.14 (1), p.23
2024
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- Autor(en) / Beteiligte
- Titel
- Compounds from Agathisdammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
- Ist Teil von
- Natural products and bioprospecting, 2024-12, Vol.14 (1), p.23
- Ort / Verlag
- Singapore: Springer Nature Singapore
- Erscheinungsjahr
- 2024
- Quelle
- EZB Free E-Journals
- Beschreibungen/Notizen
- In this study, two new kaurane diterpenes (1 6 , 17 ), together with 12 lignans ( 1–12 ), a triterpene ( 15 ), and two other compounds ( 13 , 14 ) were isolated from the woods of Agathis dammara . The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5 , 11 , 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish. Graphical Abstract
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2192-2195eISSN: 2192-2209DOI: 10.1007/s13659-024-00440-4Titel-ID: cdi_proquest_journals_2973341720
- Format
- –
- Schlagworte
- Ablation, Absolute configuration, Biomedical and Life Sciences, Bioorganic Chemistry, Carbon, Chirality, Circular dichroism, Danio rerio, Dichroism, Excitons, Food Science, Glucose, Life Sciences, Lignans, Magnetic resonance spectroscopy, Medicinal Chemistry, Natural products, NMR spectroscopy, Original Article, Pharmacology/Toxicology, Plant Biochemistry, Plant Sciences, Spectrum analysis, Terpenes, Zebrafish