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Software defect prediction is one of the most popular research topics in software engineering. The objective of defect prediction is to identify defective instances prior to the occurrence of software defects, thus it aids in more effectively prioritizing software quality assurance efforts. In this article, we delve into various prospective research directions and potential challenges in the field of defect prediction. The aim of this article is to propose a range of defect prediction techniques and methodologies for the future. These ideas are intended to enhance the practicality, explainability, and actionability of the predictions of defect models.