Details

Autor(en) / Beteiligte

• Elbadry, Mohamed
• Badawi, Mahmoud
• Youssef, Naglaa
• Duracinsky, Martin
• Saleh, Shereen A.
• Funk, Anna
• Elessawy, Hagar
• Rumpler, Eva
• Sayed, Khadiga
• Vasiliu, Anca
• Madec, Yoann
• Fontanet, Arnaud
• El-Kassas, Mohamed

Titel

Impact of treating chronic hepatitis C with direct acting antivirals on health-related quality of life: a real-life Egyptian experience

Ist Teil von

• Egyptian Liver Journal, 2024-02, Vol.14 (1), p.14, Article 14

Ort / Verlag

Menoufiya: Springer Nature B.V

Erscheinungsjahr

2024

Beschreibungen/Notizen

• Abstract Background Chronic hepatitis C virus (HCV) infection negatively impacts health-related quality of life (HRQL). We aimed to assess patient-reported outcomes (PROs) to evaluate the impact of treating chronic HCV with directly acting antivirals (DAAs) on HRQL. Methods PROs were assessed prospectively using the PROQOL-HCV questionnaire before (week 0), at the end (week 12), and after DAA treatment at week 24. HRQL was measured in six different dimensions: physical health, emotional health, future uncertainty, intimate relationships, social health, and cognitive functions. Results A total of 500 HCV patients receiving DAAs were enrolled; of them, 399 were included in the analysis (median age 57 years, 59% females). HRQL increased significantly between baseline, end of treatment, and week 24 for all dimensions ( P  < 0.001), more often for physical health in females compared to males (OR = 1.69, 95% CI = 1.1–2.5), for future uncertainty among people with diabetes (1.75, 95% CI = 1.05–2.9), and for cognitive functions among obese patients (OR = 1.98; 95% CI = 1.1–3.3). Improvement in HRQL was less common for intimate relations among females (OR = 0.47; 95% CI = 0.3–0.7) and in patients with cirrhosis (OR = 0.35, 95% CI = 0.1–0.7). Improvement in HRQL was consistently higher in < 60 years compared to ≥ 60 years patients, with a significant difference in social health ( P  < 0.001) and future uncertainty ( P  < 0.049) HRQL domains. Conclusion HRQL improved with DAA therapy, a relation consistent across all HRQL dimensions up to 12 weeks after the end of treatment.