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Individual Responses to Creatine Supplementation on Muscular Power is Modulated by Gene Polymorphisms in Military Recruits
Ist Teil von
Journal of science in sport and exercise (Online), 2023-02, Vol.5 (1), p.70-76
Ort / Verlag
Singapore: Springer Nature Singapore
Erscheinungsjahr
2023
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Purpose
The aim was to explore five established SNPs (rs1815739, rs1805086, rs2700352, rs28497577, and rs28357094) that are known to modulate skeletal muscle protein kinetics in response to creatine supplementation.
Methods
A randomized, placebo-controlled, repeated measures design was used. Participants (
n
= 152) were randomized divided into one of two groups: CREA (20 g/day creatine monohydrate) or PLAC: (dextrose) for 7 days. SNP were assessed, and participants were classified accordingly. Before and after supplementation, anthropometrics (height and body mass) and performance measures (vertical jump, countermovement vertical jump, squat jump, abdominal crunches, and maximum push-ups) were assessed.
Results
CREA gained more body mass than PLAC (CREA: ∆0.864 ± 0.06 kg; PLAC: ∆0.154 ± 0.07 kg,
P
< 0.001). In the CREA group, the presence of an A allele for the
MYLK1
polymorphism was related to changes in countermovement jump height (
P
= 0.027; effect size [
d
] = 0.41) and leg power (
P
= 0.040, effect size [
d
] = 0.18). The total number of abdominal crunches after supplementation was influenced by treatments and
SPP1
gene (
P
= 0.041). A higher number of abdominal crunches was associated with the G allele in the CREA group and the TT genotype in the PLAC group (effect size [
d
] = 0.04).
Conclusion
Collectively, short-term creatine supplementation increased body mass but was unable to alter muscle performance. However, following creatine supplementation, participants expressing A alleles in the
MYLK1
polymorphism had a greater increase in jump height and leg power and participants expressing G alleles in the
SPP1
gene had greater improvements in abdominal crunch performance.